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KMID : 1144120150050040289
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Biomedical Engineering Letters
2015 Volume.5 No. 4 p.289 ~ p.295
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Analysis of force acting on the non-spherical particle near a wall
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Lee Sei-Young
Hyun Ji-Yeon
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Abstract
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Purpose: To investigate the non-spherical particle dynamics near a wall in a vasculature, it is required that detailed force with respect to the particle angle and separation distance. The prismatic particles with different cross sections are employed to study the forces on the particle in linear shear flow.
Methods: The force on the particle at the proximity of the wall in linear shear flow is evaluated. Fluid dynamics simulation is performed by using Fluent software. To investigate the effect of particle non-sphericity, triangular, rectangular and hexagonal prisms are considered.
Results: As the particle places close to the wall, the interaction between particle and wall increase. Due to the particle nonsphericity, the periodic force fluctuation is observed and this feature is important as the particle approaches to the wall. The number of apex of the cross sectional geometry is significant on the force on the particle by fluid.
Conclusions: The interaction between particle and the wall induces force imbalance so that it is predicted that the particle geometry will influence on the particle dynamics in the vascular flow. The particle cross sectional shape and particle non-sphericity are important factors in designing particlebased drug delivery system.
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KEYWORD
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Drug delivery system, Shear flow, Drag and resistant force, Non-spherical particle, Migration
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